Shp-1 genecards

Author: tjza

August undefined, 2024

SHP-1 gene has two promoters: P-1, active in epithelial cells, and P-2, active in hemopoietic cells. In addition the expression of SHP-1 is low in epithelial cells and high in hemopoietic cells. SHP-1 level in epithelial cells increases and in hematopoietic cells decreases in cancer. WebFeb 15, 2004 · SHP-1, an src homology 2 (SH2) domain containing protein tyrosine phosphatase, functions as a negative regulator of signaling downstream of cytokine receptors, receptor tyrosine kinases and receptor complexes of the immune system.

A novel SHP-1/Grb2–dependent mechanism of negative regulation …

WebHuman Gene PTPN6 (uc010sfr.1) Description: Homo sapiens protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 2, mRNA. RefSeq Summary (NM_002831): The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular ... slow cooker poached chicken breast

Some Chicago GIS Data - University of Chicago

WebMar 1, 2005 · Because Shp-1, an SH2 domain-containing PTP, is expressed primarily in hematopoietic cells, we examined whether Shp-1 activity could regulate IL-4-dependent … WebMar 20, 2024 · 说明： 1.shp格式资源为小编在最新版卫星地图上慢慢抠出来的，由于不同年份季度之间湖泊水量存在变化，所以不能保证上传的矢量图层为完全准确的，但抠图过程都尽量将卫星图放大以提高图层的准确性，请考虑充分后选择是否下载，并自审后决定使用。 WebJun 1, 2010 · Src homology region 2 domain-containing phosphatase 1 (SHP-1) has been implicated as a potential cancer therapeutic target by its negative regulation of immune cell activation and the activity of the SHP-1 inhibitor sodium stibogluconate that induced IFN-gamma (+) cells for anti-tumor action. slow cooker polynesian chicken recipe

The function of the protein tyrosine phosphatase SHP-1 in cancer

WebIt is always a good idea to project Chicago GIS data. Good projections for the Chicago area include the Illinois East state plane projection and UTM Zone 16. Most of the files … WebMar 21, 2024 · GeneCards Summary for PTPN6 Gene PTPN6 (Protein Tyrosine Phosphatase Non-Receptor Type 6) is a Protein Coding gene. Diseases associated with PTPN6 include … slow cooker poached pears in white wineWebDescription: Homo sapiens programmed cell death 1 (PDCD1), mRNA. (from RefSeq NM_005018) RefSeq Summary (NM_005018): This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in ... slow cooker poached eggs

"WebMar 27, 2024 · GeneCards is a searchable, integrative database that provides comprehensive, user-friendly information on all annotated and predicted human genes. … " - Shp-1 genecards

Shp-1 genecards

Human Gene FLT3 (ENST00000241453.12) from GENCODE V43

WebReceptor Insulinolikog faktora rasta 1 (IGF-1) jest protein ćelijske površine koji je kod ljudi kodiran genom IGF-1 sa hromosoma 15.To je transmembranski receptor koji se aktivira hormonom koji se zove insulinoliki faktor rasta 1 i srodnim hormonom zvanim IGF-2.Pripada velikoj klasi tirozin-kinaznih receptora. Ovaj receptor posreduje u efektima IGF-1, koji je … WebApr 11, 2016 · SHP-1 [protein tyrosine phosphatase, non-receptor type 6 (PTPN6)] is expressed by all mature haematopoietic lineages and at low levels, in a different isoform, by endothelial cells [ 19 ]. There is 95% homology between human and mouse SHP-1, making it amenable for study in pre-clinical mouse models [ 20 ].

Did you know?

WebJan 6, 2024 · The GeneCards ® database of human genes was launched in 1997 and has expanded since then to encompass gene-centric, disease-centric, and pathway-centric entities and relationships within the GeneCards Suite, effectively navigating the universe of human biological data—genes, proteins, cells, regulatory elements, biological pathways, … WebSep 29, 2024 · Here we found that Shp1 bound to phosphorylated peptide sequences derived from SIRPα and transduced the anti-phagocytic signal, as Shp1 loss in mouse bone marrow-derived macrophages increased phagocytosis of tumor cells in vitro. We also generated a novel mouse model to evaluate the impact of global, inducible Ptpn6 deletion …

WebMar 8, 2024 · The SHP-1 tyrosine phosphatase is the central negative NK cell regulator that dephosphorylates key activating signaling proteins. Though the mechanism by which SHP-1 mediates NK cell inhibition has been partially elucidated, the pathways by which SHP-1 is itself regulated remain unclear. WebThe SHP-1 gene has two promoters: the distal promoter, which is only present in epithelial cells, and the proximal promoter, which is active in both epithelial and hemopoietic cells. Therefore, under normal conditions, expression levels of SHP-1 vary between epithelial and hematopoietic cells.

WebFeb 15, 2004 · SHP-1, an src homology 2 (SH2) domain containing protein tyrosine phosphatase, functions as a negative regulator of signaling downstream of cytokine … WebJun 11, 2024 · Src homology region 2 (SH-2) domain-containing phosphatase 1 (Shp1) is a non-receptor tyrosine phosphatase encoded by the PTPN6 gene that is located on human …

WebSHP-1 Antibodies Antibodies that detect SHP-1 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, Flow Cytometry and Immunoprecipitation. These antibodies target SHP …

WebTATA-binding protein. The TATA-binding protein ( TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription … slow cooker pork and appleWebSHP is unusual for a nuclear receptor in that it lacks a DNA binding domain. Therefore, it is technically neither a transcription factor nor nuclear receptor but nevertheless it is still … slow cooker polynesian chickenWebJun 26, 2024 · The Src homology region 2 domain-containing phosphatase 1 (SHP-1, encoded by the Shp1/Ptpn6 gene) is a non-receptor tyrosine phosphatase expressed in hematopoietic cells and, at a lower level, in epithelial cells. It is known to exert a negative regulatory effect on cellular signaling in cells of both the innate and adaptive immune … slow cooker polish sausage and sauerkrautWebJun 26, 2024 · We generated Shp1 transgenic (Shp1-Tg) mice to study the impact of SHP-1 overexpression on arthritis susceptibility and adaptive immune responses. SHP-1 gene … slow cooker porcupine meatballs recipeWebInterferon Regulatory Factor 1: Protein Coding: 53: GC05M132440: 2.00: 14: ALK: ALK Receptor Tyrosine Kinase: Protein Coding: 59: GC02M029190: 1.99: 15: NPM1: … GeneCards Search Guide Search Features. GeneCards uses stemming in all of its … slow cooker plum pudding for christmasWeb18935 Ensembl ENSG00000109132 ENSMUSG00000012520 UniProt Q99453 O35690 RefSeq (mRNK) NM_003924 NM_008888 RefSeq (bjelančevina) NP_003915 NP_032914 Lokacija (UCSC) Chr 4: 41.74 – 41.75 Mb Chr 5: 67.25 – 67.26 Mb PubMed pretraga Wikipodaci Pogledaj/uredi – čovjek Pogledaj/uredi – miš Upareni homeoboks 2b … slow cooker pork and pineapple curryWebApr 15, 2024 · けする探偵はもう、死んでいる。第1巻《シエスタ -水着ver.- 1／7スケールフィギュア付き完全数量限定版》 [Blu-ray]：COCOHOUSE ブランド【クマパック】カスタムアイシードールワンカールパープルの通販 by Rep2☆'s shop｜ラクマをつけてい slow cooker pork and sauerkraut