WebJun 25, 2011 · A sequence variant of histone H2A called H2AX is one of the key components of chromatin involved in DNA damage response induced by different genotoxic stresses. Phosphorylated H2AX (γH2AX) is rapidly concentrated in chromatin domains around DNA double-strand breaks (DSBs) after the action of ionizing radiation or chemical … WebGet better batch-to-batch reproducibility with a recombinant antibody. Anti-gamma H2A.X (phospho S139) antibody [EP854 (2)Y] (ab81299) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production. Success from the first experiment ...
Cytosolic accumulation of γH2AX is associated with ... - Nature
H2A histone family member X (usually abbreviated as H2AX) is a type of histone protein from the H2A family encoded by the H2AFX gene. An important phosphorylated form is γH2AX (S139), which forms when double-strand breaks appear. In humans and other eukaryotes, the DNA is wrapped around histone octamers, consisting of core histones H2A, H2B, H3 and H4, to form chromatin. H2AX contributes to nucleosome-formation, chr… WebJul 9, 2024 · The H2AX histone protein is rapidly phosphorylated at the serine-139 position (γH2AX) in response to a broad range of DNA lesions. γH2AX induction is one of the earliest events in the DNA damage response (DDR) and plays … poplapay castles
γH2AX: a sensitive molecular marker of DNA damage and repair
WebWithin minutes of the induction of DNA double-strand breaks in somatic cells, histone H2AX becomes phosphorylated in the serine 139 residue at the damage site. The … WebMar 28, 2014 · The nuclear foci of phosphorylated histone H2AX (γH2AX) are frequently used as a marker for DNA double-strand breaks (DSBs) following ionizing radiation (IR). However, recent studies reported... WebSep 4, 2024 · After DSB formation, rapid phosphorylation of the core histone variant H2AX at serine 139 is induced in adjacent chromatin, leading to the formation of a γH2AX focus . Initially, γH2AX was detected by two-dimensional gel electrophoresis, but generation of specific antibodies enabled the development of more sensitive γH2AX immunoassays ( 2 … pop landing page bankofamerica.com