Hif bcl-2
Web23 de abr. de 2008 · In this study, we demonstrate expression of HIF-1α, Epo, EpoR and bcl-2 in ONB and report a significant correlation between HIF-1α and bcl-2 expression … WebAims and methods: Hypoxia-inducible factor (HIF-1) which contains oxygen regulated HIF-1alpha subunit maintains cytoprotective defence against hypoxic injury by induction of …
Hif bcl-2
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Web15 de out. de 2013 · Hypoxia-inducible factor 1-alpha (HIF-1α) is a subunit of HIF-l and thought to be able to protect hypoxic cells from apoptosis or necrosis under ischemic and … WebBcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90. Trisciuoglio D , Gabellini C , Desideri M , Ziparo E , Zupi G , Del …
WebHIF-1a and bcl-2 was found in neuroblastoma [17]. This study thoroughly investigated the mechanism by which bcl-2 regulates HIF-1 in tumour cells exposed to hypoxic conditions. It identified the stabilization of HIF-1a protein as a mechanism by which bcl-2 induces the activation of HIF-1 in hypoxic melanoma cells, through the impairment of ... Web17 de ago. de 2012 · Immunohistological expressions of HIF‐1α, GLUT‐1, Bcl‐2 and Ki‐67 were investigated in biopsies taken before treatment, after 2, 4 and 6 weeks of CRT and in specimens from the operation. Decreasing expressions of HIF‐1α, Bcl‐2 and Ki‐67 were observed during CRT, whereas GLUT‐1 overall was unchanged.
Web目的探讨熊果酸对喉癌Hep-2细胞B淋巴细胞瘤-2(Bcl-2)、凋亡相关因子Bcl-2相关X蛋白(Bax)基因表达及凋亡的影响。方法选取Hep-2喉鳞状细胞癌细胞接种于96孔板中培养,随机分为A、B、C组,每组10个复孔,A组给予常规培养,B组在此基础给予50.0μmol·L(-1)熊果酸,C组给予6μmol·L(-1)熊果酸,C组给予6μmol·L(-1)顺铂。 WebCell lysates collected from cells treated with 0.5 µM, 5 µM, and 50 µM of HIF-1α/HIF-2α translation inhibitors were analyzed with western blot analysis for BAX and Bcl-2 levels.
Web1 de dez. de 2024 · N-Ras can protect cells against apoptosis by increasing the ratio of Bcl-2 to Bax. 41 Isoform-specific knockout experiments demonstrate that skeletal muscle differentiation is directly affected by H-Ras and K-Ras, whereas N-Ras has a vital role in preserving cell survival by acting as an anti-apoptotic protein. 42 According to the results …
Web26 de jul. de 2010 · (A) Western blot analysis of HIF-1α protein expression in M14 control cells (puro) and bcl-2 stably overexpressing (Bcl2/5, Bcl2/37) clones treated with 17-AAG under hypoxia or exposed to normoxia for 24 h. (B) HRE-dependent transcriptional activity in the cells treated with 17-AAG from 0.05 to 2 µM under hypoxia or exposed to normoxia … great vow buddhist monasteryWebPCR results showed that the expressions of Bax and Fas were lower (Fig. 8: B and D), but the expressions of Bcl-2 and HIF-1a were higher (Fig. 8: C and E) in the hyp group than in the nor group. florida dcfs abuse hotlineWebIn addition to act as an antiapoptotic protein, B-cell lymphoma (bcl)-2 can also promote tumor angiogenesis. In this context, we have previously demonstrated that under hypoxia … great vowel shift exampleWebHá 1 dia · BMA-155Cl treatment promoted Beclin-1, LC3B, p53, p-p53, and Bax expression, whereas decreased Bcl-2, an pivotal anti-apoptotic protein, in HepG-2 cells [87]. Among the compounds formed by Rh (III), Ru (II), Zn (II), or Mn (II) with 1 to 4 of lysicamine (LY), compounds 2 and 3 of LY presented high anti-tumor activity against HepG2 cells, which … florida dcf level of careWebHIF-1a and bcl-2 was found in neuroblastoma [17]. This study thoroughly investigated the mechanism by which bcl-2 regulates HIF-1 in tumour cells exposed to hypoxic … florida dcf statisticsWebThese molecules primarily downregulate HIF-1α and its downstream target genes causing inhibition of OSCC cell proliferation and induced expression of apoptosis regulatory … florida dcf security agreementWeb27 de jul. de 2010 · Background Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is a critical mediator of the cellular response to hypoxia. Enhanced levels of HIF-1α, … great volume shampoo