Dethiobiotin synthetase

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August undefined, 2024

WebSep 5, 1995 · The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to … WebDethiobiotin synthetase. Dethiobiotin synthetase. Dethiobiotin synthetase Methods Enzymol. 1979;62:348-52. doi: 10.1016/0076-6879(79)62241-3. Authors M A Eisenberg, …

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WebProtein target information for Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial (thale cress). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. WebMar 28, 1995 · One of these enzymes, ATP-dependent dethiobiotin synthetase, catalyzes the carboxylation of 7,8-diaminopelargonic acid leading to the formation of the ureido ring of biotin. The enzyme belongs to the class of ATP-dependent carboxylases and we present here the first crystal structure determined for this class of enzyme. grand prix gtp air intake temps post blower

945387 - Gene ResultbioD dethiobiotin synthetase []

Biotin synthase (BioB) (EC 2.8.1.6) is an enzyme that catalyzes the conversion of dethiobiotin (DTB) to biotin; this is the final step in the biotin biosynthetic pathway. Biotin, also known as vitamin B7, is a cofactor used in carboxylation, decarboxylation, and transcarboxylation reactions in many organisms including humans. Biotin synthase is an S-Adenosylmethionine (SAM) dependent enzym… Webdethiobiotin synthetase Synonyms: Evidence for Translation: Charge (pH 7)-7.44 Kyte-Doolittle Hydrophobicity Value: 0.323 Molecular Weight (kDa) 23.6 Isoelectric Point (pI) 5.02 Subcellular localization. Individual Mappings: Localization Confidence PMID; Cytoplasmic ... WebJan 6, 2004 · The structure reveals a nearly symmetric 222 tetramer, in which each bifunctional monomer contains a dethiobiotin synthetase-like amidoligase N-terminal domain and a Type 1 glutamine amidotransferase C-terminal domain. For each amidoligase active site, essential ATP- and UTP-binding surfaces are contributed by three … chinese ner using lattice lstm复现

Biochemical and Structural Characterization of the

Dethiobiotin synthase - Wikipedia

WebMay 8, 1995 · The crystal structures of six complexes of homodimeric Escherichia coli dethiobiotin synthetase with a variety of substrates, substrate analogs, and products … WebMay 8, 1995 · 1DAD, 1DAE, 1DAF, 1DAG, 1DAH, 1DAI. PubMed Abstract: The crystal structures of six complexes of homodimeric Escherichia coli dethiobiotin synthetase with a variety of substrates, substrate analogs, … grand prix go kart myrtle beachWebThe creative, dynamic city is so popular, in fact, National Geographic selected Atlanta as one of the top destinations to visit in the National Geographic Best of the World 2024 list, … chinese nettle crossword

"WebDethiobiotin synthetase (DTBS; E.C. 6.6.6.6), the penultimate enzyme in the biosynthesis of the essential vitamin biotin, is a new potential target for novel herbicides. Inhibitors … " - Dethiobiotin synthetase

Dethiobiotin synthetase

WebThis article is cited by 32 publications. Andrew P. Thompson, Wanisa Salaemae, Jordan L. Pederick, Andrew D. Abell, Grant W. Booker, John B. Bruning, Kate L. Wegener, Steven W. Polyak. Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes. WebJan 1, 1979 · This chapter presents an overview of dethiobiotin (DTB) synthetase. The interrelationship between 7,8-diaminopelargonic acid and DTB has been first established when both vitamers have been found to satisfy the biotin requirement of …

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WebMay 8, 1995 · These include (1) the binary complex of dethiobiotin synthetase and the N7-carbamate of 7,8-diaminononanoic acid, (2) the binary complex of enzyme and the alternate substrate, 3-(1-aminoethyl)-nonanedioic acid, (3) the binary complex of enzyme with the product ADP, (4) the quaternary complex of enzyme, ADP, the N7-carbamate of 7,8 ... WebSep 5, 1995 · Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF 3 -diaminopelargonic acid and enzyme-MgADP-dethiobiotin …

WebSep 5, 1995 · Dethiobiotin synthetase (DTBS) catalyzes the penultimate step in biotin biosynthesis, the formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (7,8-diaminopelargonic acid, DAPA), CO2, and ATP. Solutions of DAPA at neutral pH readily formed a mixture of the N7- and N8-carbamates in the …

WebApr 30, 2012 · The Two-Step Synthesis of DTB from KAPA. (A) In bacteria, DTB is synthesized from KAPA by two distinct enzymes encoded by bioA and bioD genes, respectively, catalyzing successively DAPA-AT and DTBS reactions. AdoMTOB, S -adenosyl-2-oxo-4-methylthiobutyric acid. WebThe levels of dethiobiotin synthetase in Escherichia co2i have been increased 6-fold over the wild type when pre- pared from a X-lysogen carrying the bioD gene under phage control. The purification procedure employed gave a nearly …

WebApr 16, 2010 · Dethiobiotin synthetase (DTBS) is involved in the biosynthesis of biotin in bacteria, fungi, and plants. As humans lack this pathway, DTBS is a promising antimicrobial drug target. We determined structures of DTBS from Helicobacter pylori (hpDTBS) bound with cofactors and a substrate analog, and described its unique characteristics relative to ...

WebProtein target information for Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial (thale cress). Find diseases associated with this … chinese nesting booden chestsWebThe levels of dethiobiotin synthetase in Escherichia co2i have been increased 6-fold over the wild type when pre- pared from a X-lysogen carrying the bioD gene under phage … grand prix golf chamonixWebMar 31, 1998 · The ATP-dependent enzyme dethiobiotin synthetase from Escherichia coli catalyses the formation of dethiobiotin from CO2 and 7, 8-diaminopelargonic acid. The … chinese net slang sofaWebDethiobiotin synthetase from Mycobacterium tuberculosis (MtDTBS) is a promising antituberculosis drug target. Small-molecule inhibitors that target MtDTBS provide a route towards new therapeutics for the treatment of antibiotic-resistant tuberculosis. Adenosine diphosphate (ADP) is an inhibitor of MtDTBS; however, structural studies into its ... chinese nesting tablesWebD-Desthiobiotin. (Synonyms: Dethiobiotin) Cat. No.: HY-128699 Purity: 98.19%. COA Handling Instructions. D-Desthiobiotin is a biotin derivative used in affinity … chinese network catchwordsWebMay 1, 1994 · Background In Escherichia coli, the enzymes of the biotin biosynthesis pathway are encoded by the bio operon. One of these enzymes, ATP-dependent dethiobiotin synthetase, catalyzes the carboxylation of 7,8-diaminopelargonic acid leading to the formation of the ureido ring of biotin. The enzyme belongs to the class of ATP … grand prix gtp coupe for saleWebIn addition, the synthetase domain is homologous to dethiobiotin synthase, 198 an enzyme that forms an iminophosphate intermediate during catalytic turnover. 199 The … grand prix gtp goes slower with 3.5 pulley