Camptothecin prodrug
WebDec 16, 2024 · A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane–naphthalimide fluorescent camptothecin … WebA novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed. You have access to this article
Camptothecin prodrug
Did you know?
WebIntroduction. Camptothecin (CPT) is a naturally occurring alkaloid with potent antineoplastic activity against a broad spectrum of solid tumors (eg, primary and metastatic colon … WebKeywords: CPT prodrug, dual responsive, sequential drug release, prostate-specific membrane antigen, ... Li Y, Lin J, Ma J, et al. Methotrexate–camptothecin prodrug nanoassemblies as a versatile nanoplatform for biomodal imaging-guided self-active targeted and synergistic chemotherapy.
WebCyclosert- camptothecin is a linear, cyclodextrin-based polymer (CDP) and camptothecin (CPT) conjugate. CPT, an alkaloid extract, displays anticancer activity as an inhibitor of … WebHerein, we fabricated a novel amphiphilic lactose-camptothecin prodrug molecular Lac-SS-CPT which can self-assemble into Lac-SS-CPT glyco-nano prodrug system for GSH responsive and targeted drug co-delivery due to the existence of disulfide bond and lactose. 41–44 Then, the CPT-based glyco-nano prodrug system further provides a suitable ...
National Center for Biotechnology Information WebOct 15, 2006 · A folate receptor targeted camptothecin prodrug was synthesized using a hydrophilic peptide spacer linked to folate via a releasable disulfide carbonate …
WebDespite the use of intensive multimodality therapy, the majority of high-risk neuroblastoma (NB) patients do not survive. Without significant improvements in delivery strategies, anticancer agents used as a first-line treatment for high-risk tumors often fail to provide clinically meaningful results in the settings of disseminated, recurrent, or refractory …
WebDec 1, 2024 · To increase drug loading and combination therapy, we covalently conjugated paclitaxel (PTX) and camptothecin (CPT) through a disulfide linker into a prodrug, designated PTX-S-S-CPT. The... first squad cdaWebIntroduction. Camptothecin (CPT) is a naturally occurring alkaloid with potent antineoplastic activity against a broad spectrum of solid tumors (eg, primary and metastatic colon carcinoma, small cell lung carcinoma, and ovarian, breast, pancreatic, and stomach cancers), which inhibits DNA topoisomerase I. 1 SN38 (7-ethyl-10-hydroxyl … first square of a crossword crossword clueWebGlucuronide camptothecin is a type of prodrug produced from camptothecin and glucuronide. Glucuronide, which is also referred to as glucuronoside, is substance produced by linking glucuronic acid to another substance via a glycosidic bond. The prodrug could catalyze and produce the drug camptothecin (CPT), which was discovered in 1966. first squad impactWebA camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations - Chemical Communications (RSC Publishing) Issue 84, 2024 Previous Article Next Article From the journal: Chemical Communications A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations † first spring flowers bloomingWebSep 20, 2024 · The construction of prodrug and glucose oxidase coloaded alginate (ALG) hydrogels for PDT-combined chemotherapy of melanoma will provide a promising injectable hydrogel platform for effective treatments of cancer. Biomimetic nanoprodrugs from fatty acid modified camptothecin and albumin for enhanced pharmacotherapy. first spyro game releaseWebSep 20, 2024 · Minimizing drug leakage in systemic circulation, synchronizing the in vivo fate of multiple drugs, and precisely controlling tumor locoregional drug release, remain … campbell county greenwood map serverWebJan 23, 2024 · Bio-(8)-MB-CPT thus exerted strong toxicity towards cervical cancer cells, but unlike the parent drug (camptothecin), showed no toxicity towards normal cells. Moreover, the prodrug displayed significantly enhanced antitumor efficacy in vivo and eradicated the tumor with no obvious side effects (inhibition of the tumor reached up to 99.9 %). campbell county game and fish ky